Cross-species oncogenomics using zebrafish models of cancer Journal Article


Author: White, R. M.
Article Title: Cross-species oncogenomics using zebrafish models of cancer
Abstract: The zebrafish is a relatively recent addition to cancer modeling. These models have now been extensively used in cross-species oncogenomic analyses at both the DNA and RNA levels. The goal of such studies is to identify conserved events that occur in both human and fish tumors which may act as central drivers of tumor phenotypes. Numerous comparisons of somatic DNA changes, using array CGH and exome sequencing, have demonstrated a relatively small set of conserved changes across species. In contrast, striking conservation of RNA expression patterns have been observed between the two species in models such as melanoma, leukemia, and rhabdomyosarcoma. In the future, the zebrafish will increasingly be used to model epigenetic and noncoding aspects of cancer biology. © 2015 Elsevier Ltd.
Keywords: leukemia; gene sequence; review; raf protein; nonhuman; phenotype; melanoma; gene expression; genetic variability; protein p53; tumor marker; cancer model; cancer genetics; rhabdomyosarcoma; k ras protein; species identification; beta catenin; comparative genomic hybridization; wnt protein; dna determination; genetic conservation; genomic dna; zebra fish; danio rerio; rna analysis; exome; genomic rna; species comparison; human; priority journal
Journal Title: Current Opinion in Genetics and Development
Volume: 30
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2015-02-01
Start Page: 73
End Page: 79
Language: English
DOI: 10.1016/j.gde.2015.04.006
PROVIDER: scopus
PUBMED: 26070506
PMCID: PMC4603543
DOI/URL:
Notes: Export Date: 2 September 2015 -- Source: Scopus
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  1. Richard Mark White
    29 White