Translational considerations on the outlook of immunotherapy for colorectal cancer Journal Article
| Authors: | Segal, N. H.; Saltz, L. B. |
| Article Title: | Translational considerations on the outlook of immunotherapy for colorectal cancer |
| Abstract: | Immunotherapy is an emerging strategy for many types of cancers and is already a standard treatment for malignant melanoma. Several aspects of colorectal cancer would appear to make it a good target for immunotherapy. Colorectal cancer is associated with a high mutation burden that may generate tumor-specific neo-epitopes that could elicit adaptive immune responses. Tumors with infiltrating immune cells appear to have better clinical outcome and response to chemotherapy. Patients with impaired DNA repair mechanisms have circulating antibodies and T cells that recognize resulting frameshift peptides, and anecdotal clinical responses have occurred in patients treated with immune augmentation, such as anti-PD-1, anti-PDL-1, anti-CTLA-4, and complement receptor 3-dependent cellular cytotoxicity. Yet, despite this potential, colorectal cancer is lagging behind in the development of therapeutic immunotherapy. Therefore, the rational design and interpretation of future immunotherapy studies in this disease will be pivotal to colorectal cancer joining the ranks of the “more” immunoresponsive tumors. © 2015, Springer Science+Business Media New York. |
| Keywords: | colorectal cancer; radiation; immunotherapy; dna mismatch repair deficiency; ablation; checkpoint blockade; dna mutation; immune augmentation; neo-epitope |
| Journal Title: | Current Colorectal Cancer Reports |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 1556-3790 |
| Publisher: | Springer |
| Date Published: | 2015-04-01 |
| Start Page: | 92 |
| End Page: | 97 |
| Language: | English |
| DOI: | 10.1007/s11888-015-0258-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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