AMC 048: Modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma Journal Article
| Authors: | Noy, A.; Lee, J. Y.; Cesarman, E.; Ambinder, R.; Baiocchi, R.; Reid, E.; Ratner, L.; Wagner-Johnston, N.; Kaplan, L. |
| Article Title: | AMC 048: Modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma |
| Abstract: | The toxicity of dose-intensive regimens used for Burkitt lymphoma prompted modification of cyclophosphamide, vincristine, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine (CODOX-M/IVAC) for HIV-positive patients. We added rituximab, reduced and/or rescheduled cyclophosphamide and methotrexate, capped vincristine, and used combination intrathecal chemotherapy. Antibiotic prophylaxis and growth factor support were required; highly active antiretroviral therapy (HAART) was discretionary. Thirteen AIDS Malignancy Consortium centers enrolled 34 patients from 2007 to 2010. Median age was 42 years (range, 19-55 years), 32 of 34 patients were high risk, 74% had stage III to IV BL and CD4 count of 195 cells per mL (range, 0-721 cells per mL), and 5 patients (15%) had CD4 © 2015 by The American Society of Hematology. |
| Keywords: | adult; cancer survival; clinical article; treatment outcome; survival rate; overall survival; doxorubicin; cancer combination chemotherapy; drug efficacy; drug safety; cytarabine; methotrexate; rituximab; cancer staging; human immunodeficiency virus infection; follow up; prospective study; progression free survival; infection; multiple cycle treatment; pain; phase 2 clinical trial; etoposide; heart disease; kidney disease; lung disease; thrombocytopenia; weight reduction; cyclophosphamide; vincristine; continuous infusion; ifosfamide; drug fever; febrile neutropenia; tumor lysis syndrome; myelodysplastic syndrome; feasibility study; folinic acid; cancer fatigue; mental disease; skin disease; cd4 lymphocyte count; highly active antiretroviral therapy; virus load; eye disease; antibiotic prophylaxis; neurologic disease; granulocyte colony stimulating factor; gastrointestinal disease; metabolic disorder; thorax disease; allergic reaction; musculoskeletal disease; burkitt lymphoma; vascular disease; pegfilgrastim; chemotherapy induced anemia; human; male; female; priority journal; article; hiv associated burkitt lymphoma |
| Journal Title: | Blood |
| Volume: | 126 |
| Issue: | 2 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2015-07-09 |
| Start Page: | 160 |
| End Page: | 166 |
| Language: | English |
| DOI: | 10.1182/blood-2015-01-623900 |
| PROVIDER: | scopus |
| PMCID: | PMC4497960 |
| PUBMED: | 25957391 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
