Approach to therapy of diffuse large B-cell lymphoma in the elderly: The International Society of Geriatric Oncology (SIOG) expert position commentary Journal Article
| Authors: | Morrison, V. A.; Hamlin, P.; Soubeyran, P.; Stauder, R.; Wadhwa, P.; Aapro, M.; Lichtman, S. M. |
| Article Title: | Approach to therapy of diffuse large B-cell lymphoma in the elderly: The International Society of Geriatric Oncology (SIOG) expert position commentary |
| Abstract: | Diffuse large B-cell lymphoma (DLBCL) is a treatable and potentially curable malignancy that is increasing in prevalence in the elderly. Until recently, older patients with this malignancy were under-represented on clinical treatment trials, so optimal therapeutic approaches for these patients were generally extrapolated from the treatment of younger patients with this disorder. Because of heightened toxicity concerns, older patients were sometimes given reduced dose therapy, potentially negatively impacting outcome. Geriatric considerations including functional status and comorbidities often were not accounted for in treatment decisions. Because of these issues as well as the lack of treatment guidelines for the elderly population, the International Society of Geriatric Oncology convened an expert panel to review DLBCL treatment in the elderly and develop consensus guidelines for therapeutic approaches in this patient population. The following treatment guidelines address initial DLBCL therapy, in both limited and advanced stage disease, as well as approaches to the relapsed and refractory patient. © 2014 The Author. |
| Keywords: | cancer survival; aged; overall survival; prednisone; neutropenia; review; cancer recurrence; salvage therapy; cisplatin; doxorubicin; interferon; unspecified side effect; gemcitabine; cancer radiotherapy; ibritumomab tiuxetan; methotrexate; rituximab; cancer staging; neurotoxicity; positron emission tomography; alpha2b interferon; cancer immunotherapy; progression free survival; multiple cycle treatment; nephrotoxicity; etoposide; prevalence; maintenance therapy; cyclophosphamide; vincristine; ifosfamide; febrile neutropenia; drug response; comorbidity; medical society; single drug dose; bleomycin; consensus development; radiation therapy; large cell lymphoma; malnutrition; anthracycline; oxaliplatin; leukemia relapse; elderly; functional status; induction chemotherapy; geriatric assessment; leukemia remission; central nervous system disease; b-cell lymphoma; pirarubicin; failure free survival; frailty; chemoimmunotherapy; consolidation chemotherapy; very elderly; intention to treat analysis; prognosis; human; priority journal |
| Journal Title: | Annals of Oncology |
| Volume: | 26 |
| Issue: | 6 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2015-06-01 |
| Start Page: | 1058 |
| End Page: | 1068 |
| Language: | English |
| DOI: | 10.1093/annonc/mdv018 |
| PROVIDER: | scopus |
| PUBMED: | 25635006 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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