Vaccines for melanoma: Translating basic immunology into new therapies Journal Article


Authors: Wolchok, J. D.; Livingston, P. O.
Article Title: Vaccines for melanoma: Translating basic immunology into new therapies
Abstract: Advances in molecular biology and immunology in the past 10-15 years have allowed for a greater understanding of the molecules present on melanoma cells that are recognised by the immune system. The rising incidence of melanoma, combined with lack of efficacy of cytotoxic therapies, means there is a significant need for the development of effective immunotherapies. We discuss three types of vaccine for melanoma, which are currently in phase III clinical trials: allogeneic and autologous cellular vaccines, and carbohydrate vaccines. We also discuss several new areas of vaccine development, including DNA vaccines, dendritic-cell-based vaccines, peptide vaccines, and heat-shock protein vaccines. Although initial clinical trials have shown the safety and immunological efficacy of vaccines for melanoma, the true clinical benefit of these strategies will only be revealed in large randomised trials.
Keywords: immunotherapy; molecular biology; drugs, investigational; clinical trials; vaccines; melanoma -- drug therapy; melanoma -- immunology
Journal Title: Lancet Oncology
Volume: 2
Issue: 4
ISSN: 1470-2045
Publisher: Elsevier Science, Inc.  
Date Published: 2001-04-01
Start Page: 205
End Page: 211
Language: English
ACCESSION: 2002027839
PROVIDER: EBSCOhost
PUBMED: 11905765
PROVIDER: cin20
DOI: 10.1016/S1470-2045(00)00290-4
DOI/URL:
Notes: Accession Number: 2002027839 -- Entry Date: 20020222 -- Revision Date: 20030131 -- Publication Type: journal article; pictorial; review; tables/charts -- Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland -- NLM UID: 100957246 -- Source: cin20
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Jedd D Wolchok
    905 Wolchok