The unpredictability of prolonged activation of stress response pathways Journal Article
| Authors: | Lamech, L. T.; Haynes, C. M. |
| Article Title: | The unpredictability of prolonged activation of stress response pathways |
| Abstract: | In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictabiliiy of prolonged activation should be considered. |
| Keywords: | transcription factor; stress; er; caenorhabditis-elegans; endoplasmic-reticulum; c-elegans; molecular chaperones; unfolded-protein-response; life-span; heat-shock factor-1; mitochondrial upr |
| Journal Title: | Journal of Cell Biology |
| Volume: | 209 |
| Issue: | 6 |
| ISSN: | 0021-9525 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2015-06-22 |
| Start Page: | 781 |
| End Page: | 787 |
| Language: | English |
| ACCESSION: | WOS:000356998200004 |
| DOI: | 10.1083/jcb.201503107 |
| PROVIDER: | wos |
| PMCID: | PMC4477854 |
| PUBMED: | 26101215 |
| Notes: | Review -- Source: Wos |
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