Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology Journal Article
| Authors: | Suzuki, M.; Curran, K. J.; Cheung, N. K. V. |
| Article Title: | Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology |
| Abstract: | Cancer immunotherapy using antigen-specific T cells has broad therapeutic potential. Chimeric antigen receptors and bispecific antibodies can redirect T cells to kill tumors without human leukocyte antigens (HLA) restriction. Key determinants of clinical potential include the choice of target antigen, antibody specificity, antibody affinity, tumor accessibility, T cell persistence, and tumor immune evasion. For pediatric cancers, additional constraints include their propensity for bulky metastatic disease and the concern for late toxicities from treatment. Nonetheless, the recent preclinical and clinical developments of these T cell based therapies are highly encouraging. © 2015 Wiley Periodicals, Inc. |
| Keywords: | t cells; immunotherapy; pediatric oncology; chimeric antigen receptors; bispecific antibodies |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 62 |
| Issue: | 8 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2015-08-01 |
| Start Page: | 1326 |
| End Page: | 1336 |
| Language: | English |
| DOI: | 10.1002/pbc.25513 |
| PROVIDER: | scopus |
| PUBMED: | 25832831 |
| PMCID: | PMC4976492 |
| DOI/URL: | |
| Notes: | Export Date: 3 August 2015 -- Source: Scopus |
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