Vulvar myxoid liposarcoma and well differentiated liposarcoma with molecular cytogenetic confirmation: Case reports with review of malignant lipomatous tumors of the vulva Journal Article
| Authors: | Schoolmeester, J. K.; Leifer, A. J.; Wang, L.; Hameed, M. R. |
| Article Title: | Vulvar myxoid liposarcoma and well differentiated liposarcoma with molecular cytogenetic confirmation: Case reports with review of malignant lipomatous tumors of the vulva |
| Abstract: | Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors. © 2015 International Society of Gynecological Pathologists. |
| Keywords: | adult; human tissue; aged; clinical feature; histopathology; case report; nuclear magnetic resonance imaging; computer assisted tomography; gene amplification; cytogenetics; fluorescence in situ hybridization; gene rearrangement; needle biopsy; chromosome analysis; liposarcoma; protein mdm2; myxosarcoma; growth arrest and dna damage inducible protein 153; local excision; vulva; myxoid; vulva tumor; well differentiated liposarcoma; image guided biopsy; human; female; priority journal; article; fused in sarcoma protein |
| Journal Title: | International Journal of Gynecological Pathology |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 0277-1691 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2015-07-01 |
| Start Page: | 390 |
| End Page: | 395 |
| Language: | English |
| DOI: | 10.1097/pgp.0000000000000170 |
| PROVIDER: | scopus |
| PUBMED: | 25851712 |
| DOI/URL: | |
| Notes: | Export Date: 3 August 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work