Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP Journal Article
| Authors: | Ren, F.; Geng, Y.; Minami, T.; Qiu, Y.; Feng, Y.; Liu, C.; Zhao, J.; Fan, X.; Wang, Y.; Li, M.; Li, J.; Chang, Z. |
| Article Title: | Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP |
| Abstract: | Abstract STAT3 is associated with embryo development and survival as well as proliferation and metastasis of tumor cells. In a previous study, we demonstrated that STAT3-Interacting Protein As a Repressor (SIPAR) enhances the dephosphorylation of STAT3 and negatively regulates its activity. However, it remains unclear how SIPAR inhibits phosphorylation of STAT3. Here we demonstrate that SIPAR directly interacts with T cell protein tyrosine phosphatase TC45 and enhances its association with STAT3. This interaction triggers an accelerated dephosphorylation process for STAT3. Furthermore, SIPAR inhibits the transcriptional activity of STAT3 in wild-type MEF cells but not in TC45 null MEF cells. These results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus. © 2015 Federation of European Biochemical Societies. |
| Keywords: | signal transduction; unclassified drug; human cell; nonhuman; animal cell; mouse; stat3 protein; protein protein interaction; cell line; genetic transcription; wild type; cell nucleus; protein tyrosine phosphatase; protein dephosphorylation; protein inhibitor; stat3; dephosphorylation; human; priority journal; article; stat3-interacting protein as a repressor; t cell protein tyrosine phosphatase tc45; stat3 interacting protein as a repressor; mef cell line |
| Journal Title: | FEBS Letters |
| Volume: | 589 |
| Issue: | 15 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-07-08 |
| Start Page: | 1890 |
| End Page: | 1896 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2015.05.031 |
| PROVIDER: | scopus |
| PUBMED: | 26026268 |
| DOI/URL: | |
| Notes: | Export Date: 3 August 2015 -- Source: Scopus |
