NHEJ deficiency and disease Journal Article
| Authors: | Pierce, A. J.; Jasin, M. |
| Article Title: | NHEJ deficiency and disease |
| Abstract: | In mouse and human, diseases associated with deficiency of DNA ligase IV, a protein involved in DNA double-strand break repair, have been identified. Manifestation of some of these disease phenotypes, namely tumorigenesis, may require additional checkpoint deficiencies. |
| Keywords: | mutation; nonhuman; neoplasms; protein analysis; phenotype; animals; mice; dna repair; genetic predisposition to disease; carcinogenesis; dna strand breakage; double stranded dna; short survey; disease models, animal; polydeoxyribonucleotide synthase; enzyme subunit; dna cleavage; dna ligases; enzyme deficiency; nonhomologous end joining; humans; human |
| Journal Title: | Molecular Cell |
| Volume: | 8 |
| Issue: | 6 |
| ISSN: | 1097-2765 |
| Publisher: | Cell Press |
| Date Published: | 2001-12-01 |
| Start Page: | 1160 |
| End Page: | 1161 |
| Language: | English |
| DOI: | 10.1016/s1097-2765(01)00424-5 |
| PUBMED: | 11885597 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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