The therapeutic significance of mutational signatures from DNA repair deficiency in cancer Journal Article
| Authors: | Ma, J.; Setton, J.; Lee, N. Y.; Riaz, N.; Powell, S. N. |
| Article Title: | The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
| Abstract: | Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair pathways are well established to increase lifetime cancer risk. Computational analysis of pan-cancer data has identified signatures of mutational processes thought to be responsible for the pattern of mutations in any given cancer. These analyses identified altered DNA repair pathways in a much broader spectrum of cancers than previously appreciated with significant therapeutic implications. The development of DNA repair deficiency biomarkers is critical to the implementation of therapeutic targeting of repair-deficient tumors, using either DNA damaging agents or immunotherapy for the personalization of cancer therapy. © 2018, The Author(s). |
| Journal Title: | Nature Communications |
| Volume: | 9 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2018-08-17 |
| Start Page: | 3292 |
| Language: | English |
| DOI: | 10.1038/s41467-018-05228-y |
| PROVIDER: | scopus |
| PMCID: | PMC6098043 |
| PUBMED: | 30120226 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 September 2018 -- Source: Scopus |
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