Theoretical concepts and the emerging role of taxanes in adjuvant therapy Journal Article
| Author: | Norton, L. |
| Article Title: | Theoretical concepts and the emerging role of taxanes in adjuvant therapy |
| Abstract: | The proven benefits of adjuvant chemotherapy on disease-free and overall survival in breast cancer can be explained by concepts of cell kill. Interventions which result in greater log kill can be expected to produce improved clinical results. The application of log kill concepts to human breast cancer growth, which appears to follow Gompertzian kinetics, suggests not only that the use of non-cross-resistant drugs is important, but that dose-dense schedules may have an advantage over conventional schedules of drug administration. Sequential therapy may allow dose-dense administration of cytotoxic agents and encourage the integration of new biological agents into combination regimens, particularly with the taxanes. Ongoing trials in these concepts are reviewed. |
| Keywords: | cancer survival; treatment outcome; clinical trial; cytotoxic agent; doxorubicin; fluorouracil; cancer combination chemotherapy; cancer growth; conference paper; paclitaxel; cancer adjuvant therapy; chemotherapy, adjuvant; breast cancer; cyclophosphamide; breast neoplasms; docetaxel; cancer cell; tamoxifen; epirubicin; taxoids; taxane derivative; cell killing; cross resistance; adjuvant; bridged compounds; gompertzian; herceptin; humans; human; female; priority journal; log kill |
| Journal Title: | The Oncologist |
| Volume: | 6 |
| Issue: | Suppl. 3 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2001-06-01 |
| Start Page: | 30 |
| End Page: | 35 |
| Language: | English |
| PUBMED: | 11346683 |
| PROVIDER: | scopus |
| DOI: | 10.1634/theoncologist.6-suppl_3-30 |
| DOI/URL: | |
| Notes: | Presented at Symposium on Innovative Therapies in Breast Cancer; 2000 Oct 28; Valletta, Malta -- Export Date: 21 May 2015 -- Source: Scopus |
