Antiproliferative effects of allium derivatives from garlic Journal Article
| Authors: | Pinto, J. T.; Rivlin, R. S. |
| Article Title: | Antiproliferative effects of allium derivatives from garlic |
| Abstract: | There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and hormone-unresponsive cells lines respond to these derivatives. The effects shown by allium derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction. Allium derivatives appear to regulate nuclear factors involved in immune function and inflammation, as well as in cellular proliferation. Our own studies indicate that allium derivatives inhibit proliferation of the human prostate cancer cell line (LNCaP) and the human breast cancer cell line (MCF-7). Further research is required to clarify the mechanisms of inhibition of cellular proliferation by allium derivatives and to explore their potential application to cancer prevention and control. |
| Keywords: | signal transduction; controlled study; unclassified drug; human cell; antineoplastic agents; conference paper; cell proliferation; cell cycle; cell division; cancer prevention; apoptosis; breast cancer; cancer cell culture; tumor cells, cultured; breast neoplasms; prostate cancer; prostatic neoplasms; cell strain mcf 7; anchorage independent growth; mcf-7 cells; allium sativum; allyl compounds; sulfides; growth inhibition; lncap cells; plants, medicinal; garlic; human breast cancer; humans; human; male; female; mink cell focus-forming virus; allium; human prostate cancer; s allylcysteine; s allylmercaptocysteine |
| Journal Title: | Journal of Nutrition |
| Volume: | 131 |
| Issue: | 3 Suppl. |
| ISSN: | 0022-3166 |
| Publisher: | Amer Society Nutritional Science |
| Date Published: | 2001-03-01 |
| Start Page: | 1058S |
| End Page: | 1060S |
| Language: | English |
| PUBMED: | 11238816 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Presented at the Conference on Recent Advances on the Nutritional Benefits Acaompanying the Use of Garlic as a Supplement; 1998 Nov 15-17; New port Beach, CA -- Source: Scopus |
