A unique folate hydrolase, prostate-specific membrane antigen (PSMA): A target for immunotherapy? Journal Article


Authors: Tasch, J.; Gong, M.; Sadelain, M.; Heston, W. D. W.
Article Title: A unique folate hydrolase, prostate-specific membrane antigen (PSMA): A target for immunotherapy?
Abstract: Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This review discusses the historical background, biochemical characteristics, gene regulation, potential for targeting, tissue localization, and a novel T-body strategy.
Keywords: androgen; conference paper; drug targeting; protein domain; antigen expression; animals; mice; cancer immunotherapy; prostatic neoplasms; molecular cloning; cloning, molecular; capromab pendetide in 111; prostate specific membrane antigen; antibodies, monoclonal; prostate; immunotherapy; cancer vaccine; tissue distribution; cancer vaccines; nucleotide sequence; alternative splicing; growth regulation; alternative rna splicing; gene therapy; gene control; binding sites; glutamate carboxypeptidase ii; antigens, surface; psma; gamma glutamyl hydrolase; acid phosphatase prostate isoenzyme; hormone dependence; cancer; humans; human; male; priority journal; carboxypeptidases
Journal Title: Critical Reviews in Immunology
Volume: 21
Issue: 1-3
ISSN: 1040-8401
Publisher: Begell House, Inc  
Date Published: 2001-01-01
Start Page: 249
End Page: 261
Language: English
PUBMED: 11642607
PROVIDER: scopus
DOI: 10.1615/CritRevImmunol.v21.i1-3.160
DOI/URL:
Notes: Presented at the 10th International Symposium on Immunobiology of Proteins and Peptides; 2000 Sep 12-16; Tahoe City, CA -- Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Michel W J Sadelain
    453 Sadelain
  2. Michael Gong
    8 Gong