Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma Journal Article
| Authors: | Jarnagin, W. R.; Fong, Y.; DeMatteo, R. P.; Gonen, M.; Burke, E. C.; Bodniewicz, J.; Youssef, M.; Klimstra, D.; Blumgart, L. H. |
| Article Title: | Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma |
| Abstract: | Objective: To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors. Summary Background Data: In patients with hilar cholangiocarcinoma, long-term survival depends critically on complete tumor resection. The current staging systems ignore factors related to local tumor extent, preclude accurate preoperative disease assessment, and correlate poorly with resectability and survival. Methods: Demographics, results of imaging studies, surgical findings, pathology, and survival were analyzed prospectively in consecutive patients. Using data from imaging studies, all patients were placed into one of three stages based on the extent of ductal involvement by tumor, the presence or absence of portal vein compromise, and the presence or absence of hepatic lobar atrophy. Results: From March 1991 through December 2000, 225 patients were evaluated, 77% of whom were seen and treated within the last 6 years. Sixty-five patients had unresectable disease; 160 patients underwent exploration with curative intent. Eighty patients underwent resection: 62 (78%) had a concomitant hepatic resection and 62 (78%) hadan Ro resection (negative histologic margins). Negative histologic margins, concomitant partial hepatectomy, and well-differentiated tumor histology were associated with improved outcome after all resections. However, in patients who underwent an Ro resection, concomitant partial hepatectomy was the only independent predictor of long-term survival. Of the 9 actual 5-year survivors (of 30 at risk), all had a concomitant hepatic resection and none had tumor-involved margins; 3 of these 9 patients remained free of disease at a median follow-up of 88 months. The rates of complications and death after resection were 64% and 10%, respectively. In the 219 patients whose disease could be staged, the proposed system predicted resectability and the likelihood of an RO resection and correlated with metastatic disease and survival. Conclusion: By taking full account of local tumor extent, the proposed staging system for hilar cholangiocarcinoma accurately predicts resectability, the likelihood of metastatic disease, and survival. Complete resection remains the only therapy that offers the possibility of long-term survival, and hepatic resection is a critical component of the surgical approach. |
| Keywords: | adult; cancer survival; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; cancer surgery; survival rate; major clinical study; histopathology; cancer localization; conference paper; preoperative care; cancer staging; follow up; follow-up studies; magnetic resonance imaging; neoplasm staging; preoperative evaluation; prospective studies; surgical approach; survival time; probability; hepatectomy; bile duct carcinoma; biliary tract surgery; bile duct neoplasms; bile ducts, intrahepatic; cholangiocarcinoma; metastasis potential; humans; human; male; female; priority journal; hemihepatectomy |
| Journal Title: | Annals of Surgery |
| Volume: | 234 |
| Issue: | 4 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2001-10-01 |
| Start Page: | 507 |
| End Page: | 519 |
| Language: | English |
| DOI: | 10.1097/00000658-200110000-00010 |
| PUBMED: | 11573044 |
| PROVIDER: | scopus |
| PMCID: | PMC1422074 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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