| Abstract: |
The mouse is an ideal model system for studying the molecular mechanisms underlying the pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has been instrumental in determining the role of major determinants in this process, such as oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the mouse has increased in its complexity, allowing in vivo dissection of the fundamental concepts underlying cooperative oncogenesis in various tumor types. In this review, we discuss how this transition has been facilitated, providing relevant examples. We also review how, in the post-genome era, novel methodologies will further accelerate the study of multi-step tumorigenesis in the mouse. |
| Keywords: |
mutation; review; cancer growth; nonhuman; animals; mice; mice, knockout; gene targeting; skin neoplasms; epidermis; skin cancer; protein p53; cancer model; morphology; carcinogenesis; transgenic mouse; animalia; mus musculus; mice, transgenic; receptors, virus; cancer inhibition; oncogene; tumor suppressor gene; acute myeloblastic leukemia; promyelocytic leukemia; neoplasms, experimental; protein kinase c; virus infection; disease models, animal; comparative genomic hybridization; knockout mouse; retrovirus; transforming growth factor alpha; knockout gene; gene transfer techniques; virus gene; protein c jun; avian proteins; unidentified retrovirus; humans; human; priority journal; 7,12 dimethylbenz[a]anthracene; oncogene c fos
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