The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family Journal Article
| Authors: | Mogil, J. S.; Pasternak, G. W. |
| Article Title: | The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family |
| Abstract: | The isolation of an opioid receptor-related clone soon led to the isolation and characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This heptadecapeptide binds to the NOP1 (previously termed ORL1) receptor with exceedingly high affinity, but does not interact directly with classical opioid receptors. Functionally, the actions of OFQ/N are diverse and intriguing. Most work has focused upon pain mechanisms, where OFQ/N has potent anti-analgesic actions supraspinally and analgesic actions spinally. Other OFQ/N activities are less clear. The diversity of responses might reflect NOP1 receptor heterogeneity, but this remains to be established. The actions of this neurochemical system may also be uniquely dependent on contextual factors, both genetic and environmental. This review will address the molecular biology and behavioral pharmacology of OFQ/N and its receptor. |
| Keywords: | controlled study; review; nonhuman; mouse; animals; mice; pain; animal experiment; animal model; drug effect; drug receptor binding; molecular cloning; cloning, molecular; brain; rats; morphine; molecular biology; memory; motor activity; analgesia; receptor gene; vasodilator agents; hyperalgesia; naloxone; fentanyl; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide; enkephalin[2,5 dextro penicillamine]; naltrexone; opioid peptides; cyclazocine; pentazocine; neurochemistry; dynorphin a; nociceptin; leucine enkephalin; opiate peptide; enkephalin[2 dextro alanine 4 methylphenylalanine 5 glycine]; levallorphan; receptors, opioid; humans; priority journal; diprenorphine; nociceptin receptor; metenkephalin; dynorphin b |
| Journal Title: | Pharmacological Reviews |
| Volume: | 53 |
| Issue: | 3 |
| ISSN: | 0031-6997 |
| Publisher: | The American Society for Pharmacology and Experimental Therapeutics |
| Date Published: | 2001-09-01 |
| Start Page: | 381 |
| End Page: | 415 |
| Language: | English |
| PUBMED: | 11546835 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
