Gliomagenesis: Genetic alterations and mouse models Journal Article
| Author: | Holland, E. C. |
| Article Title: | Gliomagenesis: Genetic alterations and mouse models |
| Abstract: | Glioblastoma multiforme is the most malignant of the primary brain tumours and is almost always fatal. The treatment strategies for this disease have not changed appreciably for many years and most are based on a limited understanding of the biology of the disease. However, in the past decade, characteristic genetic alterations have been identified in gliomas that might underlie the initiation or progression of the disease. Recent modelling experiments in mice are helping to delineate the molecular aetiology of this disease and are providing systems to identify and test novel and rational therapeutic strategies. |
| Keywords: | signal transduction; genetics; review; brain tumor; glioma; brain neoplasms; mouse; animal; metabolism; animals; mice; cell cycle; pathology; disease model; disease models, animal; growth substances; growth promotor |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2001-02-01 |
| Start Page: | 120 |
| End Page: | 129 |
| Language: | English |
| DOI: | 10.1038/35052535 |
| PUBMED: | 11253051 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
