Management of Kaposi sarcoma: The role of interferon and thalidomide Journal Article
| Author: | Krown, S. E. |
| Article Title: | Management of Kaposi sarcoma: The role of interferon and thalidomide |
| Abstract: | Kaposi sarcoma (KS) remains the most commonly diagnosed cancer in HIV-infected patients. Although several chemotherapeutic agents have proven effective in controlling KS, the growing understanding of the factors contributing to the development of KS has provided a stronger rationale for using noncytotoxic agents that influence the mechanisms involved in KS pathogenesis. Two such agents, interferon and thalidomide, have shown activity against KS in clinical trials and have the potential to influence multiple steps believed to be important in KS development and progression. Studies are ongoing to explore the optimal way to use these agents and their mechanisms of action. © 2001 Lippincott Williams & Wilkins, Inc. |
| Keywords: | thalidomide; drug tolerability; pathogenesis; review; interferon; drug efficacy; drug safety; combined modality therapy; human immunodeficiency virus infection; antineoplastic agent; cytokines; disease progression; effector cell; acquired immune deficiency syndrome; kaposi sarcoma; sarcoma, kaposi; immunosuppressive agents; hiv infections; interferon-alpha; antiviral agents; humans; priority journal |
| Journal Title: | Current Opinion in Oncology |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 1040-8746 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2001-09-01 |
| Start Page: | 374 |
| End Page: | 381 |
| Language: | English |
| DOI: | 10.1097/00001622-200109000-00010 |
| PUBMED: | 11555715 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
