AIDS-associated Kaposi's sarcoma: Is there still a role for interferon alfa? Journal Article
| Author: | Krown, S. E. |
| Article Title: | AIDS-associated Kaposi's sarcoma: Is there still a role for interferon alfa? |
| Abstract: | Interferon alfa (IFNα) was one of the first agents to be used therapeutically in AIDS-associated Kaposi's sarcoma (KS) more than 25 years ago, and induces tumor regression in a subset of patients. Although much has been learned about the clinical role of IFNα in KS treatment, little is currently known about the mechanism(s) by which IFNα causes KS regression. This is despite a growing understanding of both KS pathogenesis and relevant IFNα activities. To a large extent other agents have supplanted IFNα as treatments for KS, but there may still remain a therapeutic role for IFNα, possibly in combination with other agents targeting angiogenesis and/or HHV-8-encoded human gene homologs that encode proteins involved in cell cycle regulation and signaling. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | clinical trial; drug activity; neutropenia; pathogenesis; interferon; nonhuman; side effect; alpha interferon; anorexia; animals; drug dosage form comparison; tumor regression; angiogenesis; fever; drug mechanism; acquired immune deficiency syndrome; flu like syndrome; kaposi sarcoma; sarcoma, kaposi; liver function test; virus replication; cell cycle regulation; cytopenia; human herpesvirus 8; interferon-alpha; zidovudine; antiviral agents; recombinant alpha2a interferon; aids-related opportunistic infections; peginterferon alpha2a; kaposi's sarcoma; didanosine |
| Journal Title: | Cytokine & Growth Factor Reviews |
| Volume: | 18 |
| Issue: | 5-6 |
| ISSN: | 1359-6101 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2007-10-01 |
| Start Page: | 395 |
| End Page: | 402 |
| Language: | English |
| DOI: | 10.1016/j.cytogfr.2007.06.005 |
| PUBMED: | 17656146 |
| PROVIDER: | scopus |
| PMCID: | PMC2041795 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: CGFRF" - "Source: Scopus" |
