Disialoganglioside G(D2) loss following monoclonal antibody therapy is rare in neuroblastoma Journal Article
| Authors: | Kramer, K.; Gerald, W. L.; Kushner, B. H.; Larson, S. M.; Hameed, M.; Cheung, N. K. V. |
| Article Title: | Disialoganglioside G(D2) loss following monoclonal antibody therapy is rare in neuroblastoma |
| Abstract: | Background. Ganglioside G(D2) is abundant on human neuroblastoma (NBI. Monoclonal antibody 3F8 targeted to G(D2) may have imaging and therapeutic potential. Antigen-negative clones can escape immune-mediated attack leading to clinical resistance or recurrence. Procedure. Among 95 evaluable patients treated intravenously with 3F8 (94 Stage 4, 1 Stage 3), 66 received nonradiolabeled 3F8, 11 received 131-iodine-labeled-3F8 (8-28 mCi/ kg] with autologous bone marrow rescue, and 18 received both forms of treatment. Prior to treatment, 90 patients tested positive for G(D2) reactivity by bone marrow immunofluorescence (n = 68), tumor immunohistochemistry (n = 20), or diagnostic radioimmunoscintigraphy (n = 2). Results. Of 62 patients who had refractory or recurrent neuroblastoma following 3F8 treatment, 61 (98%) tested positive for G(D2) reactivity by bone marrow immunofluorescence (n = 51) or tumor immunohistochemistry (n = 10). The sole tumor that lost G(D2) expression underwent phenotypic transformation into a pheochromocytoma-like tumor. Conclusions. The persistence of G(D2) expression in refractory or recurrent NE suggests that complete antigen loss is an uncommon event and cannot account for treatment failure. Med. Pediatr. Oncol. 36. 194-196, 2001. (C) 2001 Wiley-Liss, Inc. |
| Keywords: | immunotherapy; diagnosis; gangliosides; 3f8; human neuro-blastoma; i-131-3f8 |
| Journal Title: | Medical and Pediatric Oncology |
| Volume: | 36 |
| Issue: | 1 |
| ISSN: | 0098-1532 |
| Publisher: | Wiley Liss |
| Date Published: | 2001-01-01 |
| Start Page: | 194 |
| End Page: | 196 |
| Language: | English |
| ACCESSION: | WOS:000166167300046 |
| DOI: | 10.1002/1096-911x(20010101)36:1<194::aid-mpo1046>3.0.co;2-b |
| PROVIDER: | wos |
| PUBMED: | 11464881 |
| Notes: | Presented at the Advances in Neuroblastoma Research Meeting; 1998 Jun 15-17; Bath, England -- Source: Wos |
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