Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor Journal Article


Authors: Bridge, J. A.; Kanamori, M.; Ma, Z. G.; Pickering, D.; Hill, D. A.; Lydiatt, W.; Lui, M. Y.; Colleoni, G. W. B.; Antonescu, C. R.; Ladanyi, M.; Morris, S. W.
Article Title: Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. in a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24)].
Keywords: bone; pseudotumor; kinase; non-hodgkins-lymphoma; 2p23; chromosomal changes
Journal Title: American Journal of Pathology
Volume: 159
Issue: 2
ISSN: 0002-9440
Publisher: Elsevier Science, Inc.  
Date Published: 2001-08-01
Start Page: 411
End Page: 415
Language: English
ACCESSION: WOS:000170356500004
DOI: 10.1016/s0002-9440(10)61711-7
PROVIDER: wos
PMCID: PMC1850566
PUBMED: 11485898
Notes: Article -- Source: Wos
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MSK Authors
  1. Cristina R Antonescu
    619 Antonescu
  2. Marc Ladanyi
    885 Ladanyi
  3. Man Yee Lui
    19 Lui