Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor Journal Article
| Authors: | Butrynski, J. E.; D'adamo, D. R.; Hornick, J. L.; Cin, P. D.; Antonescu, C. R.; Jhanwar, S. C.; Ladanyi, M.; Capelletti, M.; Rodig, S. J.; Ramaiya, N.; Kwak, E. L.; Clark, J. W.; Wilner, K. D.; Christensen, J. G.; Jänne, P. A.; Maki, R. G.; Demetri, G. D.; Shapiro, G. I. |
| Article Title: | Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor |
| Abstract: | Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately half of IMTs carry rearrangements of the anaplastic lymphoma kinase (ALK) locus on chromosome 2p23, causing aberrant ALK expression. We report a sustained partial response to the ALK inhibitor crizotinib (PF-02341066, Pfizer) in a patient with ALK-translocated IMT, as compared with no observed activity in another patient without the ALK translocation. These results support the dependence of ALK-rearranged tumors on ALK-mediated signaling and suggest a therapeutic strategy for genomically identified patients with the aggressive form of this softtissue tumor. (Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.) Copyright © 2010 Massachusetts Medical Society. |
| Keywords: | immunohistochemistry; adult; treatment response; cancer surgery; young adult; gene translocation; mutation; prednisone; fatigue; case report; doxorubicin; hypophosphatemia; side effect; pyridines; positron emission tomography; antineoplastic agent; laparotomy; imatinib; computer assisted tomography; anemia; leukopenia; ifosfamide; aminotransferase blood level; arthralgia; drug dose escalation; protein kinase inhibitors; gene rearrangement; pyrazoles; fluorodeoxyglucose f 18; protein-tyrosine kinases; leg edema; hypocalcemia; receptors, growth factor; anaplastic lymphoma kinase; 3 [1 (2,6 dichloro 3 fluorophenyl)ethoxy] 5 [1 (4 piperidinyl) 1h pyrazol 4 yl] 2 pyridinylamine; foot edema; plasma cell granuloma; abdominal neoplasms; granuloma, plasma cell; neoplasms, muscle tissue; proto-oncogene proteins c-met |
| Journal Title: | New England Journal of Medicine |
| Volume: | 363 |
| Issue: | 18 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 2010-10-28 |
| Start Page: | 1727 |
| End Page: | 1733 |
| Language: | English |
| DOI: | 10.1056/NEJMoa1007056 |
| PUBMED: | 20979472 |
| PROVIDER: | scopus |
| PMCID: | PMC3014292 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 20 April 2011" - "CODEN: NEJMA" - "Source: Scopus" |
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