Morphogenesis of the somatic musculature in Drosophila melanogaster Journal Article
| Authors: | Schulman, V. K.; Dobi, K. C.; Baylies, M. K. |
| Article Title: | Morphogenesis of the somatic musculature in Drosophila melanogaster |
| Abstract: | In Drosophila melanogaster, the somatic muscle system is first formed during embryogenesis, giving rise to the larval musculature. Later during metamorphosis, this system is destroyed and replaced by an entirely new set of muscles in the adult fly. Proper formation of the larval and adult muscles is critical for basic survival functions such as hatching and crawling (in the larva), walking and flying (in the adult), and feeding (at both larval and adult stages). Myogenesis, from mononucleated muscle precursor cells to multinucleated functional muscles, is driven by a number of cellular processes that have begun to be mechanistically defined. Once the mesodermal cells destined for the myogenic lineage have been specified, individual myoblasts fuse together iteratively to form syncytial myofibers. Combining cytoplasmic contents demands a level of intracellular reorganization that, most notably, leads to redistribution of the myonuclei to maximize internuclear distance. Signaling from extending myofibers induces terminal tendon cell differentiation in the ectoderm, which results in secure muscle-tendon attachments that are critical for muscle contraction. Simultaneously, muscles become innervated and undergo sarcomerogenesis to establish the contractile apparatus that will facilitate movement. The cellular mechanisms governing these morphogenetic events share numerous parallels to mammalian development, and the basic unit of all muscle, the myofiber, is conserved from flies to mammals. Thus, studies of Drosophila myogenesis and comparisons to muscle development in other systems highlight conserved regulatory programs of biomedical relevance to general muscle biology and studies of muscle disease. © 2015 Wiley Periodicals, Inc. |
| Keywords: | unclassified drug; review; nonhuman; mammalia; protein; morphogenesis; immunoglobulin; protein tyrosine kinase; stem cell; drosophila melanogaster; glutamate receptor; tensin; microtubule; cell adhesion; actin polymerization; bone remodeling; integrin; cell organelle; actin related protein 2-3 complex; p21 activated kinase; laminin; rac protein; kinesin; nuclear reprogramming; myoblast; myotube; dynein adenosine triphosphatase; muscle development; protein synthesis regulation; guanine nucleotide exchange factor; adaptor protein; microtubule associated protein; phosphatidylinositide; wiskott aldrich syndrome protein; molecular motor; actin filament; channel gating; connectin; hibris protein; sticks and stones protein; sarcomere; tendon; talin; integrin linked kinase; priority journal; metamorphosis; cytoplasmic linker protein 190; domain of unknown function protein; irregular chiasm c protein; jnk interacting protein 3; muscle innervation |
| Journal Title: | Wiley Interdisciplinary Reviews: Developmental Biology |
| Volume: | 4 |
| Issue: | 4 |
| ISSN: | 1759-7684 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2015-07-01 |
| Start Page: | 313 |
| End Page: | 334 |
| Language: | English |
| DOI: | 10.1002/wdev.180 |
| PROVIDER: | scopus |
| PMCID: | PMC4456235 |
| PUBMED: | 25758712 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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