Moving stem cells to the clinic: Potential and limitations for brain repair Journal Article

   


Authors: Steinbeck, J. A.; Studer, L.
Article Title: Moving stem cells to the clinic: Potential and limitations for brain repair
Abstract: Stem cell-based therapies hold considerable promise for many currently devastating neurological disorders. Substantial progress has been made in the derivation of disease-relevant human donor cell populations. Behavioral data in relevant animal models of disease have demonstrated therapeutic efficacy for several cell-based approaches. Consequently, cGMP grade cell products are currently being developed for first in human clinical trials in select disorders. Despite the therapeutic promise, the presumed mechanism of action of donor cell populations often remains insufficiently validated. It depends greatly on the properties of the transplanted cell type and the underlying host pathology. Several new technologies have become available to probe mechanisms of action in real time and to manipulate invivo cell function and integration to enhance therapeutic efficacy. Results from such studies generate crucial insight into the nature of brain repair that can be achieved today and push the boundaries of what may be possible in the future. © 2015 Elsevier Inc.
Keywords: review; drug efficacy; cell function; in vivo study; neural stem cell; stem cell; interneuron; cell therapy; immunomodulation; pluripotent stem cell; neurologic disease; dopamine; motoneuron; cyclic gmp; oligodendroglia; brain depth stimulation; neurotransmitter; human; priority journal; cells by body anatomy
Journal Title: Neuron
Volume: 86
Issue: 1
ISSN: 0896-6273
Publisher: Cell Press  
Date Published: 2015-04-08
Start Page: 187
End Page: 206
Language: English
DOI: 10.1016/j.neuron.2015.03.002
PROVIDER: scopus
PMCID: PMC4443446
PUBMED: 25856494
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84930357522&partnerID=40&md5=2c7876dfc213b14adea6e55f06b7e4f1
Notes: Export Date: 2 July 2015 -- Source: Scopus
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MSK Authors
  1. Lorenz Studer
    220 Studer
  2. Julius Steinbeck
    8 Steinbeck
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