Results of high dose rate brachytherapy, anterior pelvic exenteration and external beam radiotherapy for carcinoma of the female urethra Journal Article
| Authors: | Dalbagni, G.; Donat, S. M.; Eschwege, P.; Herr, H. W.; Zelefsky, M. J. |
| Article Title: | Results of high dose rate brachytherapy, anterior pelvic exenteration and external beam radiotherapy for carcinoma of the female urethra |
| Abstract: | Purpose: We evaluated a multimodality approach to locally advanced urethral carcinoma in women. Materials and Methods: Between August 1996 and July 1999, 6 women were treated for locally advanced carcinoma of the urethra with anterior pelvic exenteration followed by high dose 192iridium intraoperative radiation therapy. Four of the 6 patients were also treated with neoadjuvant or concomitant platinum based chemotherapy. Results: Two patients had no evidence of disease, 3 had distant metastasis and 2 had local recurrence at a mean followup of 21 months (range 12 to 47). Radiation was relatively well tolerated with no major adverse events. Conclusions: High dose intraoperative brachytherapy followed by external beam radiation is relatively well tolerated. Local control seems to have improved. We must evaluate a larger cohort of patients to determine this impact of the combined modality on local control and patient survival. |
| Keywords: | adult; cancer chemotherapy; cancer survival; clinical article; aged; aged, 80 and over; middle aged; survival analysis; cancer recurrence; multimodality cancer therapy; cancer radiotherapy; radiation dose; combined modality therapy; follow up; neoplasm recurrence, local; radiotherapy; pelvis exenteration; carcinoma; brachytherapy; platinum; cancer control; carcinoma, transitional cell; iridium 192; urethra; urethra carcinoma; urethral neoplasms; pelvic exenteration; beam therapy; humans; human; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 166 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2001-11-01 |
| Start Page: | 1759 |
| End Page: | 1761 |
| Language: | English |
| PUBMED: | 11586218 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0022-5347(05)65669-8 |
| DOI/URL: | |
| Notes: | Export Date: 30 June 2015 -- Source: Scopus |
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