A new model for the presentation of tumor-associated antigens and the quest for an anticancer vaccine: A solution to the synthesis challenge via ring-closing metathesis Journal Article

   

Authors:	Jeon, I.; Lee, D.; Krauss, I. J.; Danishefsky, S. J.
Article Title:	A new model for the presentation of tumor-associated antigens and the quest for an anticancer vaccine: A solution to the synthesis challenge via ring-closing metathesis
Abstract:	Fully synthetic, carbohydrate-based antitumor vaccine candidates have been synthesized in highly clustered modes. Multiple copies of tumor-associated carbohydrate antigens, Tn and STn, were assembled on a single cyclic peptide scaffold in a highly convergent manner. Ring-closing metathesis-mediated incorporation of an internal cross-linker was also demonstrated. In particular, this rigidified cross-linked construct would enhance a cluster-recognizing antibody response by retaining an appropriate distance between glycans attached to the peptide platform. Details of the design and synthesis of highly clustered antigens are described herein. © 2009 American Chemical Society.
Keywords:	unclassified drug; tumor antigen; antigen presentation; amines; drug research; immune response; antigens; cancer vaccine; cancer vaccines; tumors; antibody response; peptides; synthesis (chemical); antigens, tumor-associated, carbohydrate; anti-tumors; appropriate distances; crosslinker; cyclic peptides; glycans; new model; ring closing metathesis; carbohydrates; carbohydrate antigen; glycan derivative; glycopeptide; stn antigen; tn antigen; antibody formation; glycopeptides; peptides, cyclic
Journal Title:	Journal of the American Chemical Society
Volume:	131
Issue:	40
ISSN:	0002-7863
Publisher:	American Chemical Society
Date Published:	2009-10-14
Start Page:	14337
End Page:	14344
Language:	English
DOI:	10.1021/ja9052625
PUBMED:	19746915
PROVIDER:	scopus
PMCID:	PMC2758925
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-70349905113&partnerID=40&md5=e97e50e5f8d787101023936804fead2a
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: JACSA" - "Source: Scopus"

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