Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study Journal Article

Authors: Glass, O. K.; Inman, B. A.; Broadwater, G.; Courneya, K. S.; Mackey, J. R.; Goruk, S.; Nelson, E. R.; Jasper, J.; Field, C. J.; Bain, J. R.; Muehlbauer, M.; Stevens, R. D.; Hirschey, M. D.; Jones, L. W.
Article Title: Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study
Abstract: RESULTS: The between-group delta change in cardiopulmonary function was +4.1 ml kg (-1) min(-1), favouring aerobic training (P<0.05). Significant pre-post between-group differences for five cytokine and angiogenic factors (HGF, IL-4, macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), and TNF-α) also favour the aerobic training group (P's<0.05). These reductions occurred in conjunction with nonsignificant group differences for T lymphocytes CD4(+), CD8(+), and CD8(+)/CD45RA (P<0.10). For these factors, circulating concentrations generally increased from baseline to week 12 in the aerobic training group compared with decreases or no change in the usual care group. No significant changes in any metabolic intermediates were observed. CONCLUSIONS: Aerobic training alters host availability of select immune-inflammatory effectors in patients with solid tumours; larger confirmatory studies in more homogenous samples are warranted. BACKGROUND: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. PATIENTS AND METHODS: Paired peripheral blood samples were obtained from 44 patients with solid tumours receiving cytotoxic therapy and synthetic erythropoietin (usual care; n=21) or usual care plus supervised aerobic training (n=23) for 12 weeks. Samples were characterised for changes in immune, cytokine and angiogenic factors, and metabolic intermediates. Aerobic training consisted of three supervised cycle ergometry sessions per week at 60% to 100% of peak oxygen consumption (VO2peak), 30-45 min per session, for 12 weeks following a nonlinear prescription.
Keywords: middle aged; multimodality cancer therapy; clinical trials as topic; combined modality therapy; antineoplastic agent; neoplasms; erythropoietin; antineoplastic combined chemotherapy protocols; tumor markers, biological; tumor marker; blood; pilot study; pilot projects; exercise test; oxygen consumption; kinesiotherapy; clinical trial (topic); exercise therapy; procedures; humans; human; male; female; cardiovascular function; cardiovascular physiological processes
Journal Title: British Journal of Cancer
Volume: 112
Issue: 5
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2015-03-03
Start Page: 825
End Page: 831
Language: English
DOI: 10.1038/bjc.2014.662
PUBMED: 25584487
PROVIDER: scopus
PMCID: PMC4453949
Notes: Export Date: 3 June 2015 -- Source: Scopus
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MSK Authors
  1. Lee Winston Jones
    144 Jones