Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation Journal Article

   


Authors: Papanicolaou, G. A.; Lee, Y. J.; Young, J. W.; Seshan, S. V.; Boruchov, A. M.; Chittick, G.; Momméja-Marin, H.; Glezerman, I. G.
Article Title: Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation
Abstract: Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment. © 2015 National Kidney Foundation, Inc.
Keywords: adult; cancer chemotherapy; middle aged; lenalidomide; cancer recurrence; case report; kidney failure; acute kidney failure; acute graft versus host disease; donor lymphocyte infusion; allogeneic hematopoietic stem cell transplantation; large cell lymphoma; virus load; lymphocytic infiltration; t cell depletion; cd3+ t lymphocyte; immunosuppressive treatment; kidney biopsy; graft recipient; alemtuzumab; randomized controlled trial (topic); compassionate use; polyomavirus infection; mycophenolate mofetil; bk virus; human; male; article; interstitial nephritis; bk viremia; brincidofovir; hematopoietic stem cell (hsc) transplantation; polyomavirus-associated nephropathy (pvan); kidney infection; polyomavirus associated nephropathy
Journal Title: American Journal of Kidney Diseases
Volume: 65
Issue: 5
ISSN: 0272-6386
Publisher: W.B. Saunders Co.  
Date Published: 2015-05-01
Start Page: 780
End Page: 784
Language: English
DOI: 10.1053/j.ajkd.2014.11.020
PROVIDER: scopus
PUBMED: 25600489
PMCID: PMC5916792
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84929023177&partnerID=40&md5=9c0c037002f7936cfa63f48a2c8b86e4
Notes: Export Date: 3 June 2015 -- Source: Scopus
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MSK Authors
  1. Yeon Joo Lee
    51 Lee
  2. Genovefa A Papanicolaou
    241 Papanicolaou
  3. Ilya Gregory Glezerman
    84 Glezerman
  4. James W Young
    319 Young
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