Insights into mu opioid pharmacology: The role of mu opioid receptor subtypes Journal Article
| Author: | Pasternak, G. W. |
| Article Title: | Insights into mu opioid pharmacology: The role of mu opioid receptor subtypes |
| Abstract: | Although mu opioids share many pharmacological characteristics, they also reveal many differences. Many approaches over the years have suggested the existence of multiple mu opioid receptors. The unique selectivities of naloxonazine, for example, provided a way of distinguishing mu1 from mu2 actions. Studies of morphine-6β-gluruconide suggested that its actions involved yet another mu opioid receptor subtype. The cloning of a mu opioid receptor, MOR-1, provided a way of exploring this possibility at the molecular level. Recent studies have now identified a number of splice variants of this gene that appear to be important in the production of mu opioid analgesia. © 2001 Elsevier Science Inc. |
| Keywords: | unclassified drug; nonhuman; animals; opiate; down-regulation; drug selectivity; molecular cloning; cloning, molecular; drug mechanism; rna, messenger; alternative splicing; trans-activators; morphine; analgesia; protein variant; mu opiate receptor; receptors, opioid, mu; rna splicing; naloxone; fentanyl; diamorphine; splicing; receptor subtype; naloxonazine; mor-1; morphine-6-glucuronide; mu opioid receptor; drug cross tolerance; morphine derivatives; narcotics; naloxazone; humans; human; article; m6g |
| Journal Title: | Life Sciences |
| Volume: | 68 |
| Issue: | 19-20 |
| ISSN: | 0024-3205 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2001-04-06 |
| Start Page: | 2213 |
| End Page: | 2219 |
| Language: | English |
| DOI: | 10.1016/s0024-3205(01)01008-6 |
| PUBMED: | 11368076 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
