Total syntheses of tumor-related antigens N3: Probing the feasibility limits of the glycal assembly method Journal Article

  


Authors: Kim, H. M.; Kim, I. J.; Danishefsky, S. J.
Article Title: Total syntheses of tumor-related antigens N3: Probing the feasibility limits of the glycal assembly method
Abstract: The total syntheses of two octasaccharide antigens isolated from human milk, 1 and 2, and their corresponding allyl glycosides, 3 and 4, have been achieved by utilizing the glycal method. Convergent assembly of the core hexasaccharides and concurrent introduction of two α-L-fucosyl moieties at the late stage of the syntheses provided these complex carbohydrates in a concise manner. With synthetic material obtained, biological evaluations of these antigens as potential gastrointestinal cancer immunotherapeutic agents have been initiated.
Keywords: complex formation; cancer immunotherapy; tumor antigen; cancer research; digestive system cancer; antibodies, monoclonal; molecular sequence data; molecular interaction; enzyme-linked immunosorbent assay; antigens, tumor-associated, carbohydrate; carbohydrate sequence; allyl compound; carbohydrate derivative; glycoside; oligosaccharides; carbohydrate synthesis; humans; female; article; milk, human
Journal Title: Journal of the American Chemical Society
Volume: 123
Issue: 1
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2001-01-10
Start Page: 35
End Page: 48
Language: English
DOI: 10.1021/ja0022730
PUBMED: 11273599
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0035835041&partnerID=40&md5=cf5147f32e55c60938f0573409bb27d8
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. In Jong Kim
    10 Kim
  2. Samuel J Danishefsky
    539 Danishefsky
  3. Hyunjin Kim
    6 Kim
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