Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance Journal Article
| Authors: | Seo, S. K.; Regan, A.; Cihlar, T.; Lin, D. C.; Boulad, F.; George, D.; Prasad, V. K.; Kiehn, T. E.; Polsky, B. |
| Article Title: | Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance |
| Abstract: | We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents. |
| Keywords: | child; genetics; case report; pathophysiology; virology; antibiotic resistance; drug combination; brain ventricle; drug derivative; antivirus agent; cidofovir; drug combinations; immune deficiency; immunocompromised host; bone marrow transplantation; foscarnet; ganciclovir; drug resistance, viral; antiviral agents; organophosphorus compounds; phosphonic acid derivative; cerebral ventricles; cytosine; virus encephalitis; retinitis; organophosphorus compound; encephalitis, viral; phosphonic acids; humans; human; female; article; cytomegalovirus retinitis |
| Journal Title: | Clinical Infectious Diseases |
| Volume: | 33 |
| Issue: | 9 |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press |
| Date Published: | 2001-11-01 |
| Start Page: | e105 |
| End Page: | e108 |
| Language: | English |
| PUBMED: | 11577375 |
| PROVIDER: | scopus |
| DOI: | 10.1086/323022 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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