Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma Journal Article


Authors: Allen, P. J.; Busam, K.; Hill, A. D. K.; Stojadinovic, A.; Coit, D. G.
Article Title: Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma
Abstract: BACKGROUND. Immunohistochemical analysis of sentinel lymph nodes from patients with breast carcinoma and melanoma has been shown to increase the sensitivity for detecting lymph node metastases. To the authors' knowledge, this technique has not been described in patients with Merkel cell carcinoma. METHODS. Lymphatic mapping and sentinel lymph node biopsy was performed on 26 patients with Merkel cell carcinoma between 1997 and 1999. All sentinel lymph nodes were analyzed with conventional hematoxylin and eosin (H&E) staining and then analyzed with immunohistochemical staining to evaluate whether this additional technique would increase the number of patients found to have lymph node metastasis. RESULTS. The median age of the patients in the current study was 67 years and the median tumor size at the time of presentation was 2 cm. Lymph node metastases were identified in 5 of the 26 patients (19%). Three of these five lymph node positive patients were identified with H&E staining. The remaining two patients were identified only after immunohistochemical analysis. The median follow-up in this group of lymph node positive patients was 14 months, with 2 of the 5 lymph node positive patients developing a recurrence. The median follow-up in the 21 patients who were lymph node negative was 19 months, with only 1 patient having developed a recurrence at the time of last follow-up. CONCLUSIONS. Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma appears to increase the sensitivity of detecting clinically occult lymph node metastases. © 2001 American Cancer Society.
Keywords: immunohistochemistry; adult; clinical article; aged; aged, 80 and over; middle aged; cancer recurrence; follow-up studies; lymph node metastasis; cancer diagnosis; lymph nodes; lymphatic metastasis; diagnostic accuracy; sentinel lymph node; sentinel lymph node biopsy; melanoma; skin neoplasms; breast carcinoma; staining; merkel cell tumor; carcinoma, merkel cell; lymphatic mapping; merkel cell; humans; human; male; female; priority journal; article
Journal Title: Cancer
Volume: 92
Issue: 6
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2001-09-15
Start Page: 1650
End Page: 1655
Language: English
DOI: 10.1002/1097-0142(20010915)92:6<1650::aid-cncr1491>3.0.co;2-8
PUBMED: 11745244
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Arnold D Hill
    16 Hill
  2. Peter Allen
    445 Allen
  3. Daniel Coit
    423 Coit
  4. Klaus J Busam
    545 Busam