Sentinel lymph node analysis in patients with sweat gland carcinoma Journal Article
| Authors: | Delgado, R.; Kraus, D.; Coit, D. G.; Busam, K. J. |
| Article Title: | Sentinel lymph node analysis in patients with sweat gland carcinoma |
| Abstract: | BACKGROUND. Sentinel lymph node mapping and biopsy (SLNB) has become a standard staging procedure for patients with cutaneous neoplasms of known metastatic potential. In the current study, the authors explored the use of SLNB in patients with primary sweat gland carcinomas (SGCs). METHODS. Six patients with SGC underwent SLNB. The tumors and lymph nodes were examined using routine hematoxylin and eosin (H&E) stained sections and by immunohistochemistry using antibodies against epithelial membrane antigen and cytokeratins. RESULTS. Metastases were detected in the SLNs of four of the six patients with SGC. One patient with a primary tumor of the neck was found to have bilateral positive SLNs. Tumor deposits were detected by H&E stained sections alone in all but two SLNs, in which the metastatic cells were recognized only with the aid of immunohistochemical stains. Positive non-SLNs were found in two patients after complete regional lymph node dissection was performed. CONCLUSIONS. The high frequency of positive SLNs in this small series suggests that SLNB is a useful staging tool for patients with SGC. As in SLNBs of other tumors, immunohistochemistry appears to facilitate the recognition of small microscopic metastases. © 2003 American Cancer Society. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; aged, 80 and over; middle aged; cancer staging; lymph node metastasis; staging; lymph node dissection; lymph nodes; lymphatic metastasis; lymphoscintigraphy; sentinel lymph node biopsy; biopsy; time factors; immunoenzyme techniques; carcinoma; eosin; hematoxylin; cytokeratin; keratins; epithelial membrane antigen; sweat gland carcinoma; sweat gland neoplasms; neck tumor; ca-15-3 antigen; sweat gland; humans; human; male; female; priority journal; article; sentinel lymph node (sln); eccrine glands |
| Journal Title: | Cancer |
| Volume: | 97 |
| Issue: | 9 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2003-05-01 |
| Start Page: | 2279 |
| End Page: | 2284 |
| Language: | English |
| DOI: | 10.1002/cncr.11327 |
| PUBMED: | 12712484 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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