Prognostic role of cyclin D1 in retroperitoneal sarcomas Journal Article
| Authors: | Kim, S. H.; Cho, N. H.; Tallini, G.; Dudas, M.; Lewis, J. J.; Cordon-Cardo, C. |
| Article Title: | Prognostic role of cyclin D1 in retroperitoneal sarcomas |
| Abstract: | PURPOSE. Cyclin D1 regulates the G1 checkpoint of the cell cycle and is overexpressed in a number of cancers. This study was designed to determine if cyclin D1 overexpression had prognostic value in patients undergoing surgery with curative intent for primary retroperitoneal soft-tissue sarcoma. METHODS. Tissue was available for analysis on 79 patients who underwent resection between September 1983 and May 1997. Clinicopathologic data and follow-up was obtained from a prospective sarcoma database and a patient and family interview. Immunohistochemical analysis was used to determine overexpression (≥ 5% of nuclei labeled). Survival was analyzed using the Kaplan-Meier method, and statistical analysis was performed by using log rank testing and the Cox regression model. RESULTS. Median follow-up was 3.5 years. On univariate analysis of disease-specific mortality, significant prognostic factors were high grade (n = 42, 53%), positive microscopic margins (n = 36, 46%) or macroscopic margins (n = 15, 19%), and cyclin D1 overexpression (n = 37, 47%). On multivariate analysis, macroscopically positive margins (P = 0.02) and the combination of high grade and cyclin D1 overexpression (P = 0.04) both were associated independently with poor survival. CONCLUSION. High grade retroperitoneal sarcomas demonstrating cyclin D1 overexpression have had an extremely poor prognosis. Continued study of multiple biological markers, exemplified by cyclin D1, may aid characterization of tumor behavior and response to treatment in this diverse group of tumors. © 2001 American Cancer Society. |
| Keywords: | adult; cancer survival; controlled study; human tissue; protein expression; aged; middle aged; major clinical study; histopathology; cancer growth; follow-up studies; cancer grading; biological marker; disease association; neoplasm proteins; tumor biopsy; sarcoma; fibrosarcoma; retroperitoneal neoplasms; dermatofibroma; hemangiopericytoma; leiomyosarcoma; cyclin d1; analysis of variance; nerve sheath tumor; cell cycle g1 phase; liposarcoma; overexpression; retroperitoneal sarcoma; humans; prognosis; human; male; female; priority journal; article; high grade tumors; macroscopically tumor-positive margins; retroperitoneal soft-tissue sarcoma |
| Journal Title: | Cancer |
| Volume: | 91 |
| Issue: | 2 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2001-01-15 |
| Start Page: | 428 |
| End Page: | 434 |
| Language: | English |
| DOI: | 10.1002/1097-0142(20010115)91:2<428::aid-cncr1018>3.0.co;2-# |
| PUBMED: | 11180091 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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