Predictors of survival and recurrence in primary leiomyosarcoma Journal Article


Authors: Gladdy, R. A.; Qin, L. X.; Moraco, N.; Agaram, N. P.; Brennan, M. F.; Singer, S.
Article Title: Predictors of survival and recurrence in primary leiomyosarcoma
Abstract: Background: Leiomyosarcoma is a soft tissue sarcoma whose outcome has historically been confounded by the inclusion of gastrointestinal stromal tumors. Thus, we sought to determine the factors that predict survival and recurrence in patients with primary leiomyosarcoma alone. Methods: During 1982-2006, a total of 353 patients with primary resectable leiomyosarcoma were identified from a prospective database. Multivariate analysis was used to assess clinicopathologic factors for association with disease-specific survival (DSS). Competing risk survival analysis was used to determine factors predictive for local and distant recurrence. Results: Of 353 patients, 170 (48 %) presented with extremity, 144 (41 %) with abdominal/retroperitoneal, and 39 (11 %) with truncal tumors. Median age was 57 (range, 18-88) years, and median follow-up was 50 (range, 1-270) months. Most tumors were high grade (75 %), deep (73 %), and completely resected (97 %); median size was 6.0 (range, 0.3-45) cm. Abdominal/retroperitoneal location was associated with worse long-term DSS compared to extremity or trunk (P = 0.005). However, by multivariate analysis, only high grade and size were significant independent predictors of DSS. Overall, 139 patients (39 %) had recurrence: 51 % of those with abdominal/retroperitoneal, 33 % of extremity, and 26 % of truncal disease. Significant independent predictors for local recurrence were size and margin, whereas predictors for distant recurrence were size and grade. Site was not an independent predictor of recurrence; however, late recurrence (>5 years) occurred in 9 % of abdominal/retroperitoneal and 4 % of extremity lesions. Conclusions: Grade and size are significant independent predictors of DSS and distant recurrence. Long-term follow-up in leiomyosarcoma is important, as late recurrence continues in 6-9 % patients. © 2013 Society of Surgical Oncology.
Keywords: adult; cancer survival; aged; major clinical study; cancer recurrence; cancer risk; follow up; cancer grading; prediction; cancer size; leiomyosarcoma; disease specific survival
Journal Title: Annals of Surgical Oncology
Volume: 20
Issue: 6
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2013-06-01
Start Page: 1851
End Page: 1857
Language: English
DOI: 10.1245/s10434-013-2876-y
PROVIDER: scopus
PMCID: PMC3657306
PUBMED: 23354568
DOI/URL:
Notes: --- - "Export Date: 1 July 2013" - "CODEN: ASONF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Murray F Brennan
    774 Brennan
  2. Narasimhan P Agaram
    117 Agaram
  3. Rebecca Anne Gladdy
    6 Gladdy
  4. Li-Xuan Qin
    115 Qin
  5. Samuel Singer
    229 Singer
  6. Nicole Heather Moraco
    14 Moraco