The search for level I evidence in solid-tumor oncology Journal Article
| Authors: | Brooks, A. D.; Karpoff, H. M.; Sulimanoff, I.; Coit, D.; Brennan, M. F.; Jaques, D. P. |
| Article Title: | The search for level I evidence in solid-tumor oncology |
| Abstract: | Background: We have developed a method to identify, filter, review, and distribute the published level I evidence for solid tumor oncology. Methods: A standardized MEDLINE search identified prospective randomized controlled trials (PRCTs) in solid tumor oncology. Only PRCTs with therapeutic end points were included. All references were reviewed by a surgical oncology fellow in consultation with experts in the field. The full citations were imported into a comprehensive database. Data on statistical methods according to the Consolidated Standard of Reporting Trials statement were tabulated along with reviewer's comments. A designation of Ia was given to articles that were well designed and significant contributions to their field. The database powers a dynamic, easily searchable Web site on our intranet and is available in personal digital assistant (PDA) format. Results: By using standard search criteria, only .03% of the 11 million articles listed in MEDLINE are PRCTs concerning therapy for solid organ malignancies. Approximately 14% of reviewed articles were given a designation of Ia. Having comprehensive data readily available with intranet access or PDAs during conferences enhances their educational value and specificity. Conclusions: We have developed an exciting tool that uses a highly trained filter to screen and record the medical data available to the clinician. This information has been made available and portable by using the Internet and PDAs. |
| Keywords: | solid tumor; united states; sensitivity and specificity; evidence based medicine; evidence-based medicine; neoplasms; internet; data base; oncology; randomized controlled trials; medical oncology; medline; guidelines; databases; information storage and retrieval; humans; article; database searching; personal digital assistant; digital computer |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 8 |
| Issue: | 8 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2001-09-01 |
| Start Page: | 638 |
| End Page: | 643 |
| Language: | English |
| DOI: | 10.1007/s10434-001-0638-8 |
| PUBMED: | 11569778 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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