Synthesis of the functionalized macrocyclic core of proteasome inhibitors TMC-95A and B Journal Article
| Authors: | Lin, S.; Danishefsky, S. J. |
| Article Title: | Synthesis of the functionalized macrocyclic core of proteasome inhibitors TMC-95A and B |
| Abstract: | An ordered assembly of four building blocks (2-5) forms the basis of the synthesis of 1, which contains the core structure of TMC-95A and B - two potent proteasome inhibitore (see scheme; TIPS = triisopropylsilyl, Cbz = benzoxycarbonyl, Boc = tert-Boc = tert-butoxycarbonyl). |
| Keywords: | unclassified drug; proteasome inhibitor; enzyme inhibition; drug structure; drug synthesis; drug mechanism; natural product; structure analysis; reaction analysis; synthesis (chemical); inhibitors; antibiotics; aromatic compounds; article; tmc 95a; tmc 95b; biaryls; macrolactamization; crosss-coupling; building blocks; tmc 95c; tmc 95d |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 40 |
| Issue: | 10 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2001-05-18 |
| Start Page: | 1967 |
| End Page: | 1970 |
| Language: | English |
| DOI: | 10.1002/1521-3773(20010518)40:10<1967::aid-anie1967>3.0.co;2-q |
| PROVIDER: | scopus |
| PUBMED: | 11385688 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
