A rapid total synthesis of spirotryprostatin B: Proof of its relative and absolute stereochemistry Journal Article

  


Authors: Von Nussbaum, F.; Danishefsky, S. J.
Article Title: A rapid total synthesis of spirotryprostatin B: Proof of its relative and absolute stereochemistry
Abstract: A Mannich-insertion strategy was employed in the synthesis of cytostatic 1. The synthesis allowed the absolute and relative stereochemistry to be confirmed and yielded quantities of 1 suitable for upcoming biological testing. Boc = tert-butoxycarbonyl.
Keywords: unclassified drug; antineoplastic agent; drug structure; drug synthesis; cyclization; alkaloids; reaction analysis; chemical reaction; stereochemistry; chemical modification; hydrogenation; asymmetric synthesis; spirotryprostatin b; article; structure elucidation; mannich reactions
Journal Title: Angewandte Chemie - International Edition
Volume: 39
Issue: 12
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2000-06-16
Start Page: 2175
End Page: 2178
Language: English
DOI: 10.1002/1521-3773(20000616)39:12<2175::aid-anie2175>3.0.co;2-j
PROVIDER: scopus
PUBMED: 10941053
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034674241&partnerID=40&md5=bb86c1d115b26639691006c4ce00ede9
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
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