Expanding the pyrimidine diphosphosugar repertoire: The chemoenzymatic synthesis of amino- and acetamidoglucopyranosyl derivatives Journal Article

  

Authors:	Jiang, J.; Biggins, J. B.; Thorson, J. S.
Article Title:	Expanding the pyrimidine diphosphosugar repertoire: The chemoenzymatic synthesis of amino- and acetamidoglucopyranosyl derivatives
Abstract:	The exploitation of a unique thymidylyltransferase (E p) allows the rapid syntheses of thymidine and uridine 5′-(aminodeoxy-α-D-hexopyranosyl diphosphates), 5′(acetamidodeoxy-α-D-hexopyranosyl diphosphates), and even 5′-(aminodideoxy-α-D-hexopyranosyl diphosphates), which are amino analogues of the products from the native reaction of E p (see scheme).
Keywords:	unclassified drug; mass spectrometry; glycosylation; sugars; high performance liquid chromatography; pyrimidine derivative; phosphates; enzymes; synthesis; synthesis (chemical); magnesium ion; transferases; nucleotides; glycosyltransferase; synthetic methods; enzyme catalysis; article; glycosyl phosphate; chemoenzymatic synthesis; glucose derivative; acetamidodeoxy alpha dextro hexopyranosyl phosphate; acetamidoglucopyranosyl derivative; aminodeoxy alpha dextro hexopyranosyl phosphate; aminoglucopyranosyl derivative
Journal Title:	Angewandte Chemie - International Edition
Volume:	40
Issue:	8
ISSN:	1433-7851
Publisher:	Wiley Blackwell
Date Published:	2001-04-17
Start Page:	1502
End Page:	1505
Language:	English
DOI:	10.1002/1521-3773(20010417)40:8<1502::aid-anie1502>3.0.co;2-k
PROVIDER:	scopus
PUBMED:	11317315
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0035901648&partnerID=40&md5=1a7b12d1741adaf2ca5802537e3d38f1
Notes:	Export Date: 21 May 2015 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/73387