A perspective on breast cancer malignant progression: From cancer stem cell intra tumor heterogeneity to metastasis-initiating cells Book Section
| Authors: | Sansone, P.; Rajasekhar, V. K.; Bromberg, J. |
| Editor: | Vinagolu, R. |
| Article/Chapter Title: | A perspective on breast cancer malignant progression: From cancer stem cell intra tumor heterogeneity to metastasis-initiating cells |
| Abstract: | Breast cancer contains a hierarchy of distinct cancer cells. Accordingly, some cancer cells are more tumorigenic than others. These cells, called cancer stem cells (CSC), promote different aspects of tumorigenesis from chemoresistance to self-renewing potential. However, tumors also show high intra-/inter-tumoral heterogeneity, suggesting that multiple cell types might support tumor growth. Therefore, we may hypothesize that distinct CSCs operate in the process of tumorigenesis. © 2014 by John Wiley & Sons, Inc. All rights reserved. |
| Keywords: | breast cancer; cancer stem cells (cscs); csc intra tumor heterogeneity; metastasis-initiating cells (mics) |
| Book Title: | Cancer Stem Cells |
| ISBN: | 978-1-118-35616-6 |
| Publisher: | Wiley Blackwell |
| Publication Place: | Somerset, NJ |
| Date Published: | 2014-01-01 |
| Start Page: | 287 |
| End Page: | 294 |
| Language: | English |
| DOI: | 10.1002/9781118356203.ch22 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 22 -- Cancer Stem Cells -- 9781118356203 (ISBN); 9781118356166 (ISBN) -- Export Date: 4 May 2015 -- Source: Scopus |
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