The stress-like cancer cell state is a consistent component of tumorigenesis Journal Article
| Authors: | Baron, M.; Tagore, M.; Hunter, M. V.; Kim, I. S.; Moncada, R.; Yan, Y.; Campbell, N. R.; White, R. M.; Yanai, I. |
| Article Title: | The stress-like cancer cell state is a consistent component of tumorigenesis |
| Abstract: | Transcriptional profiling of tumors has revealed a stress-like state among the cancer cells with the concerted expression of genes such as fos, jun, and heat-shock proteins, though this has been controversial given possible dissociation-effects associated with single-cell RNA sequencing. Here, we validate the existence of this state using a combination of zebrafish melanoma modeling, spatial transcriptomics, and human samples. We found that the stress-like subpopulation of cancer cells is present from the early stages of tumorigenesis. Comparing with previously reported single-cell RNA sequencing datasets from diverse cancer types, including triple-negative breast cancer, oligodendroglioma, and pancreatic adenocarcinoma, indicated the conservation of this state during tumorigenesis. We also provide evidence that this state has higher tumor-seeding capabilities and that its induction leads to increased growth under both MEK and BRAF inhibitors. Collectively, our study supports the stress-like cells as a cancer cell state expressing a coherent set of genes and exhibiting drug-resistance properties. Copyright © 2020 Elsevier Inc. All rights reserved. |
| Keywords: | melanoma; single-cell rna-seq; cancer cell states; drug-resistant states; spatial transcriptomics; stress-like |
| Journal Title: | Cell Systems |
| Volume: | 11 |
| Issue: | 5 |
| ISSN: | 2405-4712 |
| Publisher: | Cell Press |
| Date Published: | 2020-11-18 |
| Start Page: | 536 |
| End Page: | 546.e7 |
| Language: | English |
| DOI: | 10.1016/j.cels.2020.08.018 |
| PUBMED: | 32910905 |
| PROVIDER: | scopus |
| PMCID: | PMC8027961 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |
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