Total synthesis of aspeverin via an iodine(III)-mediated oxidative cyclization Journal Article
| Author: | Levinson, A. M. |
| Article Title: | Total synthesis of aspeverin via an iodine(III)-mediated oxidative cyclization |
| Abstract: | The first total synthesis of aspeverin, a prenylated indole alkaloid isolated from Aspergillus versicolor in 2013, is described. Key steps utilized to assemble the core structure of the target include a highly diastereoselective Diels-Alder reaction, a Curtius rearrangement, and a unique strategy for installation of the geminal dimethyl group. A novel iodine(III)-initiated cyclization was then used to install the bicyclic urethane linkage distinctive to the natural product. © 2014 American Chemical Society. |
| Journal Title: | Organic Letters |
| Volume: | 16 |
| Issue: | 18 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2014-09-19 |
| Start Page: | 4904 |
| End Page: | 4907 |
| Language: | English |
| DOI: | 10.1021/ol5024163 |
| PROVIDER: | scopus |
| PUBMED: | 25171639 |
| PMCID: | PMC5633934 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
