In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments Journal Article
| Authors: | Mandal, M.; Dudkin, V. Y.; Geng, X.; Danishefsky, S. J. |
| Article Title: | In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments |
| Abstract: | Key features in the successful synthesis of hybrid-type gp-120 fragments (see picture) include β-mannosylations to construct the core trisaccharide and a fragment-coupling strategy to install the "upper" high-mannose domain. |
| Keywords: | human immunodeficiency virus infection; chemical analysis; drug design; drug synthesis; immunology; chemistry; hybrid protein; antigens; chemical structure; molecular structure; vaccine production; synthesis; synthesis (chemical); carbohydrates; glycopeptide; glycopeptides; vaccines; chemical modification; oligosaccharide; glycoconjugate; oligosaccharides; chemical reaction kinetics; viruses; human immunodeficiency virus vaccine; hiv envelope protein gp120; aids vaccines; synthetic methods; glycoconjugates; trisaccharides; mannose; trisaccharide; glycoprotein gp 120; humans; human; article; human immunodeficiency virus antigen; hiv antigens; mannosylations; oligosaccharides, branched-chain |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 43 |
| Issue: | 19 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2004-05-03 |
| Start Page: | 2557 |
| End Page: | 2561 |
| Language: | English |
| DOI: | 10.1002/anie.200353625 |
| PROVIDER: | scopus |
| PUBMED: | 15127452 |
| DOI/URL: | |
| Notes: | Angew. Chem. Int. Ed. -- Cited By (since 1996):81 -- Export Date: 16 June 2014 -- CODEN: ACIEA -- Source: Scopus |
