Computed tomographic features predictive of local recurrence in patients with early stage lung cancer treated with stereotactic body radiation therapy Journal Article


Authors: Halpenny, D.; Ridge, C. A.; Hayes, S.; Zheng, J.; Moskowitz, C. S.; Rimner, A.; Ginsberg, M. S.
Article Title: Computed tomographic features predictive of local recurrence in patients with early stage lung cancer treated with stereotactic body radiation therapy
Abstract: Introduction: The objective of this study is to identify computed tomography (CT) features of local recurrence (LR) after stereotactic body radiation therapy (SBRT) for lung cancer. Methods: Two hundred eighteen patients underwent SBRT for lung cancer from January 1st, 2006 to March 1st, 2011. Signs of LR recorded: opacity with new bulging margin, opacification of air bronchograms, enlarging pleural effusion, new or enlarging mass, and increased lung density at the treatment site. Results: A new bulging margin at the treatment site was the only feature significantly associated with LR (P<. .005). Conclusion: Most CT features classically associated with LR following conventional radiation therapy are unreliable for predicting LR following SBRT. © 2015 Elsevier Inc.
Keywords: adult; aged; middle aged; major clinical study; cancer recurrence; cancer staging; follow up; computer assisted tomography; image analysis; radiotherapy; lung cancer; computerized tomography; tomography; pleura effusion; patient treatment; stereotactic body radiation therapy; biological organs; diseases; computed tomography; non small cell lung cancer; computed tomography scanner; local recurrence; pleural effusion; computed tomographic; very elderly; human; priority journal; article; conventional radiation therapy; early-stage lung cancers; treatment sites
Journal Title: Clinical Imaging
Volume: 39
Issue: 2
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2015-03-01
Start Page: 254
End Page: 258
Language: English
DOI: 10.1016/j.clinimag.2014.12.005
PROVIDER: scopus
PUBMED: 25571791
PMCID: PMC4547627
DOI/URL:
Notes: Export Date: 4 May 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Junting Zheng
    130 Zheng
  2. Michelle S Ginsberg
    158 Ginsberg
  3. Chaya S. Moskowitz
    172 Moskowitz
  4. Andreas Rimner
    254 Rimner
  5. Sara Anne Hayes
    19 Hayes