Exploring published and novel pre-treatment CT and PET radiomics to stratify risk of progression among early-stage non-small cell lung cancer patients treated with stereotactic radiation Journal Article
| Authors: | Thor, M.; Fitzgerald, K.; Apte, A.; Hun Oh, J.; Iyer, A.; Odiase, O.; Nadeem, S.; Yorke, E. D.; Chaft, J.; Wu, A. J.; Offin, M.; Simone, C. B. 2nd; Preeshagul, I.; Gelblum, D. Y.; Gomez, D.; Deasy, J. O.; Rimner, A. |
| Article Title: | Exploring published and novel pre-treatment CT and PET radiomics to stratify risk of progression among early-stage non-small cell lung cancer patients treated with stereotactic radiation |
| Abstract: | Purpose: Disease progression after definitive stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) occurs in 20–40% of patients. Here, we explored published and novel pre-treatment CT and PET radiomics features to identify patients at risk of progression. Materials/Methods: Published CT and PET features were identified and explored along with 15 other CT and PET features in 408 consecutively treated early-stage NSCLC patients having CT and PET < 3 months pre-SBRT (training/set-aside validation subsets: n = 286/122). Features were associated with progression-free survival (PFS) using bootstrapped Cox regression (Bonferroni-corrected univariate predictor: p ≤ 0.002) and only non-strongly correlated predictors were retained (|Rs|<0.70) in forward-stepwise multivariate analysis. Results: Tumor diameter and SUVmax were the two most frequently reported features associated with progression/survival (in 6/20 and 10/20 identified studies). These two features and 12 of the 15 additional features (CT: 6; PET: 6) were candidate PFS predictors. A re-fitted model including diameter and SUVmax presented with the best performance (c-index: 0.78; log-rank p-value < 0.0001). A model built with the two best additional features (CTspiculation1 and SUVentropy) had a c-index of 0.75 (log-rank p-value < 0.0001). Conclusions: A re-fitted pre-treatment model using the two most frequently published features – tumor diameter and SUVmax – successfully stratified early-stage NSCLC patients by PFS after receiving SBRT. © 2023 Elsevier B.V. |
| Keywords: | radiation; pet; ct; non-small cell lung; early stage; cancer |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 190 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-01-01 |
| Start Page: | 109983 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2023.109983 |
| PROVIDER: | scopus |
| PUBMED: | 37926331 |
| PMCID: | PMC11233189 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Maria Thor -- Source: Scopus |
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