Radiation-induced heart disease: Pathologic abnormalities and putative mechanisms Journal Article
| Authors: | Taunk, N. K.; Haffty, B. G.; Kostis, J. B.; Goyal, S. |
| Article Title: | Radiation-induced heart disease: Pathologic abnormalities and putative mechanisms |
| Abstract: | Breast cancer is a common diagnosis in women. Breast radiation has become critical in managing patients who receive breast conserving surgery, or have certain high-risk features after mastectomy. Most patients have an excellent prognosis, therefore understanding the late effects of radiation to the chest is important. Radiation-induced heart disease (RIHD) comprises a spectrum of cardiac pathology including myocardial fibrosis and cardiomyopathy, coronary artery disease, valvular disease, pericardial disease, and arrhythmias. Tissue fibrosis is a common mediator in RIHD. Multiple pathways converge with both acute and chronic cellular, molecular, and genetic changes to result in fibrosis. In this article, we review the pathophysiology of cardiac disease related to radiation therapy to the chest. Our understanding of these mechanisms has improved substantially, but much work remains to further refine radiation delivery techniques and develop therapeutics to battle late effects of radiation. © 2015 Taunk, Haffty, Kostis and Goyal. |
| Keywords: | platelet derived growth factor; somatomedin; review; nonhuman; pathophysiology; cancer radiotherapy; breast cancer; transforming growth factor beta; heart disease; interleukin 13; interleukin 4; interleukin 8; immunoglobulin enhancer binding protein; collagen type 1; wound healing; fibrosis; fibroblast growth factor 2; matrix metalloproteinase; blood vessel injury; interleukin 6; ionizing radiation; radiation therapy; heart arrhythmia; coronary artery disease; heart; cardiomyopathy; connective tissue growth factor; tumor necrosis factor; heart function; collagen type 3; fibronectin; interleukin 1; heart muscle fibrosis; hypoxia inducible factor 1; pericardial disease; valvular heart disease; vasculitis; proteoglycan; human; monocyte chemotactic protein; radiation fibrosis; radiation side effects; radiation induced heart disease |
| Journal Title: | Frontiers in Oncology |
| Volume: | 5 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2015-02-18 |
| Start Page: | 39 |
| Language: | English |
| DOI: | 10.3389/fonc.2015.00039 |
| PROVIDER: | scopus |
| PMCID: | PMC4332338 |
| PUBMED: | 25741474 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- Source: Scopus |
