Narrative review: Cardiotoxicities and cardiac-sparing techniques in radiotherapy Review
| Authors: | Chan, M. F.; Parikh, D.; Shi, C. |
| Review Title: | Narrative review: Cardiotoxicities and cardiac-sparing techniques in radiotherapy |
| Abstract: | This review article aims to synthesize existing data on radiation-induced heart diseases in patients undergoing chest radiation therapy and also explores cardiac-sparing techniques to mitigate cardiotoxic effects. We conducted a comprehensive database search to review and consolidate data regarding chest radiotherapy and effects on the heart as well as techniques to minimize exposure to the heart. The research findings demonstrate associations between radiation exposure to cardiac substructures and subsequent cardiotoxicity. This review also stresses the importance of identifying patients at high-risk for cardiotoxicity as well as advocates for the adoption of stringent cardiac dose constraints in these patients. Advanced cardiac-sparing techniques, notably respiratory motion management, have emerged as pivotal strategies to minimize the likelihood of cardiac events. This narrative review emphasizes the critical role of these innovations in optimizing cardiac health during radiation treatment. © The Author(s) 2024. |
| Keywords: | mortality; review; chemotherapy; neoplasm; neoplasms; heart disease; radiotherapy; lung cancer; radiation injury; risk factor; radiation response; conservative treatment; heart failure; heart infarction; cardiotoxicity; radiation injuries; thorax radiography; heart arrhythmia; esophagus cancer; pericardial effusion; coronary artery disease; heart; ischemic heart disease; heart diseases; etiology; adverse event; childhood cancer survivor; procedures; organs at risk; organ sparing treatments; humans; human; radiation induced heart disease; major adverse cardiac event; breast radiotherapy; thoracic cancer; left anterior descending coronary artery; mediastinal lymphoma; cardiac sparing; lad; radiation-induced heart diseases; breath hold diving; cardiac sparing technique |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 23 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2024-01-01 |
| Start Page: | 15330338241301211 |
| Language: | English |
| DOI: | 10.1177/15330338241301211 |
| PUBMED: | 39636079 |
| PROVIDER: | scopus |
| PMCID: | PMC11622324 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Maria F. Chan -- Source: Scopus |
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