Transcription factor fusions in acute leukemia: Variations on a theme Journal Article
| Authors: | Scandura, J. M.; Boccuni, P.; Cammenga, J.; Nimer, S. D. |
| Article Title: | Transcription factor fusions in acute leukemia: Variations on a theme |
| Abstract: | The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., corepressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells. |
| Keywords: | leukemia; transcription; myosin; acute promyelocytic leukemia; beta; growth-factor-beta; acute lymphoblastic-leukemia; acute myelogenous leukemia; acute myeloid-leukemia; core-binding-factor; retinoic acid receptor; pml; pml-rar-alpha; nup98; tgf beta; heavy-chain; cbf; rar alpha; aml1/eto; human hematopoietic progenitors |
| Journal Title: | Oncogene |
| Volume: | 21 |
| Issue: | 21 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-05-13 |
| Start Page: | 3422 |
| End Page: | 3444 |
| Language: | English |
| ACCESSION: | WOS:000175633300015 |
| DOI: | 10.1038/sj/onc/1205315 |
| PROVIDER: | wos |
| PUBMED: | 12032780 |
| Notes: | Review -- Source: Wos |
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