Designed to kill: Novel menin-MLL inhibitors target MLL-rearranged leukemia Journal Article

  

Authors:	Kühn, M. W. M.; Armstrong, S. A.
Article Title:	Designed to kill: Novel menin-MLL inhibitors target MLL-rearranged leukemia
Abstract:	The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity. In this issue of Cancer Cell, Borkin and colleagues describe the development of highly potent small-molecule inhibitors of this interaction that reverse the leukemic phenotype and prolong survival in murine models of MLL-rearranged leukemia. The interaction between Menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity. In this issue of Cancer Cell, Borkin and colleagues describe the development of highly potent small-molecule inhibitors of this interaction that reverse the leukemic phenotype and prolong survival in murine models of MLL-rearranged leukemia. © 2015 Elsevier Inc.
Keywords:	murinae
Journal Title:	Cancer Cell
Volume:	27
Issue:	4
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2015-04-13
Start Page:	431
End Page:	433
Language:	English
DOI:	10.1016/j.ccell.2015.03.012
PROVIDER:	scopus
PUBMED:	25873167
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84928037424&partnerID=40&md5=14717bfec5720c81593a7d2637099599
Notes:	Export Date: 4 May 2015 -- Source: Scopus

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